(The list is in alphabetical order by title and name.)

Academic Units

Faculty of Pharmacy

Name SurnameProf.Dr. Eylem TURAN
E-Mail[email protected]
Detail
Resume

Prof.Dr. Eylem TURAN

Previous Positions

Research Areas

Selected Publications / All Publications

Name SurnameAssoc.Prof. Alptuğ Eren KARAKÜÇÜK
E-Mail[email protected]
Detail
Resume

Assoc.Prof. Alptuğ Eren KARAKÜÇÜK

2012

Previous Positions

Research Areas

Selected Publications / All Publications

Uluslararası hakemli dergilerde (SCI) yayımlanan makaleler :

1. ÖZDEMİR SAMET, ÜNER BURCU, KARAKÜÇÜK ALPTUĞ EREN, ÇELİK BURAK, SÜMER ENGİN, TAŞ ÇETİN (2023). Nanoemulsions as a Promising Carrier for Topical Delivery of Etodolac: Formulation Development and Characterization, Pharmaceutics 15 (10), 2510.

2. ŞİMŞEKLİ ÖYKÜ, BİLİNMİŞ İRFAN, ÇELİK SÜMEYYE, ARIK GİZEM, BABA ABDULLAH YÜCEL, KARAKÜÇÜK ALPTUĞ EREN, (2023). Advancing Biofilm Management through Nanoformulation Strategies: A Review of Dosage Forms and Administration Routes, Journal of Drug Targeting, 1-64.

3. GÜLBAĞ PINAR SILA, OKTAY AYŞE NUR, KARAKÜÇÜK ALPTUĞ EREN, ÇELEBİ FATMA NEVİN (2023). Formulation Strategies of Nanosuspensions for Various Administration Routes. PHARMACEUTICS, 15(5), 1520, DOI: 10.3390/pharmaceutics15051520.

4. KARAKÜÇÜK ALPTUG EREN, CANPINAR HANDE, ÇELEBI FATMA NEVIN (2022). Ritonavir nanosuspensions prepared by microfluidization with enhanced solubility and desirable immunological properties. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 27(10), 1027-1037, https://doi.org/10.1080/10837450.2022.2145309.

5. ÖZDEMİR SAMET, KARAKÜÇÜK ALPTUĞ, ÇAKIRLI EGEMEN, SÜRÜCÜ BİLGE, ÜNER BURCU, BARAK TİMUR HAKAN, BARDAKCI HİLAL (2022). Development and Characterization of Viburnum opulus L. Extract-Loaded Orodispersible Films: Potential Route of Administration for Phytochemicals. JOURNAL OF PHARMACEUTICAL INNOVATION, https://doi.org/10.1007/s12247-022-09627-z.

6. KARAKUCUK ALPTUG, TORT SERDAR, HAN SEVTAP, OKTAY AYSE NUR, CELEBI NEVIN (2021). Etodolac nanosuspension based gel for enhanced dermal delivery: in vitro and in vivo evaluation. JOURNAL OF MICROENCAPSULATION, 38(4), 218-232., Doi: 10.1080/02652048.2021.1895344.

7. KARAKÜÇÜK ALPTUG EREN,ÇELEBI FATMA NEVIN (2020). Investigation of formulation and process parameters of wet media milling to develop etodolac nanosuspensions. PHARMACEUTICAL RESEARCH, 37(111), 1-18., Doi: 10.1007/s11095-020-02815-x

8. TASHAN EMINE,KARAKÜÇÜK ALPTUG EREN,ÇELEBI FATMA NEVIN (2020). Development of Nanocrystal Ziprasidone Orally Disintegrating Tablets: Optimization by Using Design of Experiment and In Vitro Evaluation. AAPS PHARMSCITECH, 21, 115, Doi:10.1208/s12249-020-01653-9

9. OKTAY AYSE NUR,ILBASMIS TAMER SIBEL,KARAKÜÇÜK ALPTUG EREN,ÇELEBI FATMA NEVIN (2020). Screening of stabilizing agents to optimize flurbiprofen nanosuspensions using experimental design. Journal of Drug Delivery Science and Technology, 57, 101690, Doi:
10.1016/j.jddst.2020.101690.

10. KARAKÜÇÜK ALPTUG EREN,TORT SERDAR (2020). Preparation, characterization and antimicrobial activity evaluation of electrospun PCL nanofiber composites of resveratrol nanocrystals. Pharmaceutical Development and Technology, 25(10), 1216-1225., Doi:10.1080/10837450.2020.1805761.

11. TASHAN EMINE,KARAKÜÇÜK ALPTUG EREN,ÇELEBI FATMA NEVIN (2019). Optimization and in vitro evaluation of ziprasidone nanosuspensions produced by a top-down approach. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 52, 37-45., Doi:10.1016/j.jddst.2019.04.024.

12. KARAKÜÇÜK ALPTUG EREN,TEKSIN ZEYNEP SAFAK,EROGLU HAKAN,ÇELEBI FATMA NEVIN (2019). Evaluation of improved oral bioavailability of ritonavir nanosuspension. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 131, 153-158., Doi:10.1016/j.ejps.2019.02.028.

13. OKTAY AYSE NUR,KARAKÜÇÜK ALPTUG EREN,ILBASMIS TAMER SIBEL,ÇELEBI FATMA NEVIN (2018). Dermal flurbiprofen nanosuspensions: Optimization with design of experiment approach and in vitro evaluation. European Journal of Pharmaceutical Sciences, 122, 254-263., Doi: 10.1016/j.ejps.2018.07.009.

14. Aziz Zarith Asyikin,Ahmad Akil,Setapar Siti Hamidah,KARAKÜÇÜK ALPTUG EREN,Azim Muhammad Mohsin,Lokhat David,Rafatullah Mohd,Ganash Magdah (2018). Essential Oils: Extraction Techniques, Pharmaceutical And Therapeutic Potential - A Review. Current Drug Metabolism, 19(13), 1100-1110., Doi: 10.2174/1389200219666180723144850.

15. KARAKÜÇÜK ALPTUG EREN,ÇELEBI FATMA NEVIN,TEKSIN ZEYNEP SAFAK (2016). Preparation of ritonavir nanosuspensions by microfluidization using polymeric stabilizers: I. A Design of Experiment approach. European Journal of Pharmaceutical Sciences, 95, 111-121., Doi:10.1016/j.ejps.2016.05.010.

16. GÜLBAG SILA,YILMAZ USTA DUYGU,GÜLTEKIN HAZAL EZGI,OKTAY AYSE NUR,DEMIRTAS ÖZDEN,KARAKÜÇÜK ALPTUG EREN,ÇELEBI FATMA NEVIN (2016). New perspective to develop memantine orally disintegrating tablet formulations: SeDeM expert system. Pharmaceutical Development and Technology, 23(5), 512-519., Doi:10.1080/10837450.2017.1345941.

Ulusal hakemli dergilerde yayımlanan (TR Dizin) makaleler :

1. ÖZDEMİR SAMET, üNER BURCU, KARAKÜÇÜK ALPTUĞ (2023). Preparation and characterization studies of etodolac suppositories: investigation on oleaginous blends of Witepsol® H15. Journal of Research in Pharmacy 27 (2), 837-847.

2. TORT SERDAR, KARAKUCUK ALPTUG (2021). Serum Type Hyaluronic Acid Formulations: In vitro Characterization and Patch Test Study. FABAD Journal of Pharmaceutical Sciences, 46(3), 271-278. [Internet] http://dergi.fabad.org.tr/wp-content/uploads/2021/08/A-634.pdf

3. KARAKÜÇÜK ALPTUĞ EREN, TORT SERDAR (2021). Formulation, Optimization, and In-Vitro Evaluation of Hyaluronic Acid Buccal Films Containing Benzydamine Hydrochloride. Düzce Sağlık Bilimleri Enstitüsü Dergisi, 11(3), 325-330., DOI: 10.33631/duzcesbed.833024.

4. KARAKÜÇÜK ALPTUG EREN,TASHAN EMINE,ÖZTÜRK NAILE,ÇELEBI FATMA NEVIN (2021). In Vitro Caco-2 Cell Permeability Studies of Ziprasidone Hydrochloride Monohydrate Nanocrystals. Turkish Journal of Pharmaceutical Sciences, 18(2), 223-227., Doi:10.4274/tjps.galenos.2020.67366.

5. SARISALTIK YASIN DIREN,ARSLANTÜRK BINGÜL ALEV,KARAKÜÇÜK ALPTUG EREN,TEKSIN ZEYNEP SAFAK (2021). Development and validation of an HPLC method using an experimental design for analysis of amlodipine besylate and enalapril maleate in a fixed-dose combination. Turkish Journal of Pharmaceutical Sciences, 18(3), 306-318., Doi: 10.4274/tjps.galenos.2020.89725.

6. KARAKÜÇÜK ALPTUG EREN,ÖZTÜRK NAILE,ÇELEBI FATMA NEVIN (2020). Evaluation of Caco-2 cell permeability of ritonavir nanosuspensions. Istanbul Journal of Pharmacy, 50(3), 251-255.

7. TASHAN EMINE,KARAKÜÇÜK ALPTUG EREN,ÇELEBI FATMA NEVIN (2017). Orally Disintegrating Tablets: General Overview and Quality by Design Approach: Review. Turkiye Klinikleri Journal of Pharmacy Sciences, 6(1), 43-58., Doi: 10.5336/pharmsci.2017-54726.

Patentler :

1. Alptuğ Karaküçük, Nevin Çelebi, Serdar Tort, "Etodolak Nanosüspansiyonu İçeren Jel Formülasyonu", PCT/TR2021/050314, uluslararası patent (başvuru).

2. 22/10/2018, Serdar Tort, Alptuğ Karaküçük, Fiber Farma İlaç Kozmetik Tıbbi Cihazlar ve Danışmanlık Ltd. Şti. "Kitozan ve PVP Nanolifleri İçeren Kanama Durdurucu Örtü", 2016/16139, patent.

3. 21/06/2018, Nevin Çelebi, Emine Taşhan, Alptuğ Karaküçük, "Ziprasidon Hidroklorür Monohidrat (ZHM) Liyofilize Nanosüspansiyon Formülasyonu", 2017/03057 B, incelemeli patent.

4. 23/10/2017, Nevin Çelebi, Alptuğ Karaküçük, Zeynep Şafak Teksin, "Ritonavir İçeren Liyofilize Nanosüspansiyon Formülasyonu", 2016/02454 B, incelemeli patent.

5. 07/06/2016, Fiber Farma İlaç Kozmetik Tıbbi Cihazlar Eğitim ve Danışmanlık, "RESCARE", 2016/50333, Marka Tescili.

Projeler

1. "Etodolak Yüklü Nanoemülsiyonların Tasarımı Üzerine Çalışmalar", TÜBİTAK 1002, Proje Başlangıç Tarihi: 01.11.2021, Proje No: 221S147, Araştırmacı.

2. "Diklofenak Asitin Dermal Kullanımı için Nanosüspansiyon Yüklü Mikroiğne Geliştirilmesi", TÜBİTAK 2219 Yurtdışı Araştırma, Yürütücü (Beklemede).

3. "Nanosüspansiyon Bazlı Etodolak Jel Formülasyonunun Geliştirilmesi ve in vitro/ in vivo Değerlendirilmesi", TÜBİTAK 3001, Proje Başlangıç Tarihi: 15.05.2019, Proje Bitiş Tarihi: 24.07.2020, Proje No: 118S718, Proje Yürütücüsü.

4. "Siklosporinin Yeni Oral Formülasyonunun Geliştirilmesi ve İn vitro/ İn vivo Değerlendirilmesi", Gazi Üniversitesi Bilimsel Araştırma Projeleri, Proje Başlangıç Tarihi: 28.09.2017, Proje Bitiş Tarihi: 03.02.2020, Proje No 02/2017-14, Araştırmacı.

5. 2016/17 Newton Fund, Royal Academy of Engineering, Leaders In Innovation Fellowships, TÜBİTAK 2239, February 13-24, 2017, The Hoxton Holborn, London, UK.

6. "Saç Bakımında Bitkisel Kaynaklı Ürün Geliştirilmesi", PharmaSet Sağlık Ar-Ge,​ KOSGEB Ar-Ge ve İnovasyon Programı, Proje Başlangıç Tarihi: 2016, Proje Bitiş Tarihi: 2017, Proje Formülasyon ve Yazım Danışmanı (Fiber Farma).

7. "Nanokristal Teknolojisi Ile Ağızda Dağılan Tabletlerin Tasarımla Kalite (Qbd) Uygulamaları Ile Geliştirilmesi Ve Değerlendirilmesi", TÜBİTAK 1002, Proje Başlangıç Tarihi 2016, Proje Bitiş Tarihi: 2017, Proje No 215S920​, Bursiyer.

8. "Akneye Meyilli Ciltlerde ve Cilt Bakımında Etkili Yeni Nanoteknolojik Ürün Geliştirilmesi", Bilim, Teknoloji ve Sanayi Bakanlığı Teknogirişim Projesi, Proje Başlangıç Tarihi: 08/06/2015, Proje Bitiş Tarihi: 12/10/2016, Proje No 0104.TGSD, Proje Yürütücüsü.

9. "HIV Proteaz İnhibitörü Ritonavirin Yeni Nanosüspansiyon Formülasyonunun Geliştirilmesi ve İn Vitro/ İn Vivo Değerlendirilmesi", TÜBİTAK 1001, Proje Başlangıç Tarihi: 01/03/2014, Proje Bitiş Tarihi: 01/12/2016, Proje Yürütücüsü: Prof. Dr. Nevin Çelebi, Proje No 113S842, Bursiyer.

Ödüller

1. Gazi Üniversitesi Rektörlüğü Yayın Ödülü, 2020.

​2. Gazi Üniversitesi Rektörlüğü Yayın ve Patent Ödülü, 2019.

3. Gazi Üniversitesi Rektörlüğü Patent Ödülü, 2018.

4. Gazi Üniversitesi Rektörlüğü Yayın Ödülü, 2017.

5. 2016/17 Final Pitch Session Third Place, Royal Academy of Engineering, Leaders In Innovation Fellowships, London, UK.

6. Gazi Üniversitesi Rektörlüğü Proje Ödülü, 2016.

7. İş Güvenliği ve Savunma Sanayine Yönelik Kanama Durdurucu Nanoteknolojik Örtü Geliştirilmesi, ​Gazi Üniversitesi Teknoloji Transfer Ofisi - Halkbank, Fikirden İcraata 2015, Birincilik Ödülü.

8. Akne ve Uçuk Tedavisinde Etkili Resveratrolün Kombine Yöntemlerle Yeni Nanofiber Formülasyonunun Geliştirilmesi, Gazi Üniversitesi Teknoloji Transfer Ofisi - Halkbank, Fikirden İcraata 2014, Birinci Mansiyon Ödülü.

Sözlü Bildiriler :

1. Alptug Karakucuk, "Pharmaceutical Technology Application as an Undergraduate Pharmacy Course in Distance Education Processes in Turkey", ERPA
International Congresses on Education 2023, September 8-10, 2023, Cunda- Balıkesir.

2. Alptug Karakucuk, Samet Ozdemir, Burcu Uner, "Preparation and characterization of resveratrol nanosuspension loaded orodispersible films", European Federation For Pharmaceutical Sciences (EUFEPS) Tenth Anniversary pan-European Science Conference on QbD&PAT, October 4-6, 2021, Virtual Science Conference.

3. Alptug Karakucuk, Samet Ozdemir, "Development of orodispersible films: QbD approach and future prospective", Global Summit on Drug Delivery, Discovery and Pharmaceutical Formulation, September 23, 2021, Virtual Science Conference.

4. Samet Ozdemir, Alptug Karakucuk, Burak Celik, "Lipid Screening Studies For The Development Of Etodolac Loaded Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs)", III. International Aegean Symposiums on Natural & Medical Sciences, March 12-13, 2021, Izmir, Turkey.

5. Samet Ozdemir, Alptug Karakucuk, Burak Celik, "Design and evaluation of bioadhesive films for dental applications", 4th International Hippocrates Congress on Medical and Health Sciences, September 25-26, 2020, Antalya, Turkey.

6. Samet Ozdemir, Alptug Karakucuk, "Design and evaluation of oral mucoadhesive films for pharmaceuticals that have poor oral bioavailability", 4th International Medicine and Health Sciences Researchers Congress, August 22-23, 2020, Çorum, Turkey.

7. Alptug Karakucuk, "Solubility enhancement of poorly soluble drugs: A design of experiment approach to develop nanosuspensions", 23rd International Conference and Exhibition on Pharmaceutical Formulations, July 27-28, 2020, Webinar.

8. Diren Sarisaltik-Yasin, Alev Arslanturk-Bingul, Alptug Karakucuk, Zeynep Safak Teksin, "Development and validation of an HPLC method for amlodipine besylate and enalapril maleate using an experimental design and its application to solubility and dissolution tests", 12th of International Symposium on Pharmaceutical Sciences (ISOPS), June 26-29, 2018, Ankara, Turkey.

9. Sila Gulbag, Alptug Karakucuk, Basaran Mutlu-Agardan, Nevin Celebi, "Top-down production of cyclosporine A nanosuspensions for oral delivery: formulation design and characterization", European Federation For Pharmaceutical Sciences (EUFEPS) Annual Meeting 2018, May 24-26, 2018, Athens, Greece.

10. Serdar Tort, Alptug Karakucuk, "Akademik Girişimcilik", Davetli Konuşmacı, Gazi Üniversitesi Eczacılık Fakültesi FarmaEkol Öğrenci Topluluğu Sempozyumu (GaziFarmaSem), 30-31 Mart 2018, Ankara, Türkiye.

11. Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Optimization of flurbiprofen nanosuspensions with polymeric stabilizers for dermal application", GPSS International Gazi Pharma Symposium Series 2, October 11-13, 2017, Ankara, Turkey.

12. Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Optimization of flurbiprofen nanosuspensions: The QbD Approach", 7th BBBB International Conference on Pharmaceutical Sciences, October 5-7, 2017, Balatonfüred, Hungary.

13. Fiber Farma İl. Koz. Dan., "Kitozan ve PVP Kompozit Nanofiber Tabanlı Kanama Durdurucu Örtü Geliştirilmesi", Bio Startup Mena Hızlandırıcı Programı 2017 Dönemi, TEPAV, 25 Mayıs 2017, Ankara, Türkiye

14. Alptug Karakucuk, "Chitosan and PVP Composite Nanofiber Based Haemostatic Dressing", Royal Academy of Engineering, Leaders In Innovation Fellowships, February 13-24, 2017, London, UK.

15. Alptuğ Karaküçük, Nevin Çelebi, "Preparation of ritonavir nanosuspensions by microfluidization method using polymeric stabilizers: I. A design of experiment approach", 6th BBBB - Conference on Pharmaceutical Sciences: Strategies to Improve the Quality and Performance of Modern Drug Delivery Systems, September 10-12, 2015, Helsinki, Finland.

Poster Bildirileri:

1. Sila Gulbag, Alptug Karakucuk, Basaran Mutlu-Agardan, Nevin Celebi, "The Effect of Process Parameters of the Cyclosporine A Nanosuspension Produced by Wet Milling Stabilized with Hydroxypropyl methylcellulose", Controlled Release Society (CRS) Annual Meeting & Exposition, July 21-24, 2019, Valencia, Spain.

​2. Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Optimization of Dermal Flurbiprofen Nanosuspension using Design of Experiment (DoE): Development by Wet Milling", AAPS PharmSci 360 Advancing Pharmaceutical Sciences, Carriers and Communities, November 4-7, 2018, Washington DC, USA.

3. Aysenur Oktay, Sibel Isbasmis-Tamer, Alptug Karakucuk, Nevin Celebi, "Evaluation of Dermal Permeation of Flurbiprofen-Nanosuspension Based Gel Systems, 19th. International Pharmaceutical Technology Symposium (IPTS)", September 17-19, 2018, Antalya/Turkey.

4. Emine Tashan, Alptug Karakucuk, Naile Ozturk, Nevin Celebi, "In-vitro Caco-2 Permeability Studies of Ziprasidone Hydrochloride Monohydrate Nanosuspensions", 19th International Pharmaceutical Technology Symposium (IPTS), September 17-19, 2018, Antalya, Turkey.

5. Sila Gulbag, Alptug Karakucuk, Basaran Mutlu-Agardan, Nevin Celebi, "Preformulation studies of cyclosporine A nanosuspension stabilized by hydroxypropyl methylcellulose and soluplus®", 12th of International Symposium on Pharmaceutical Sciences (ISOPS), June 26-29, 2018, Ankara, Turkey.

6. Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "The effect of polymeric stabilizer on stability of optimum flurbiprofen nanosuspension", 12th of International Symposium on Pharmaceutical Sciences (ISOPS), June 26-29, 2018, Ankara, Turkey.

7. Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Evaluation of solubility and dermal permeation of flurbiprofen nanosuspension", European Federation For Pharmaceutical Sciences (EUFEPS) Annual Meeting 2018, May 24-26, 2018, Athens, Greece.

8. Alptug Karakucuk, Hakan Eroglu, Zeynep Safak Teksin, Nevin Celebi, "Preparation and analysis of in vitro- in vivo correlation of ritonavir nanosuspensions", European Federation For Pharmaceutical Sciences (EUFEPS) Annual Meeting 2018, May 24-26, 2018, Athens, Greece.

9. Sila Gulbag, Alptug Karakucuk, Basaran Mutlu-Agardan, Nevin Celebi, "Preparation and characterization of cyclosporine A nanosuspension for oral administration II: The effect of Poloxamer types on physical stability of formulations", 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 19-22, 2018, Granada, Spain.

10. Aysenur Oktay, Alptug Karakucuk, Sibel Isbasmis-Tamer, Nevin Celebi, "Optimization of flurbiprofen nanosuspensions using full factorial design for dermal application", 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 19-22, 2018, Granada, Spain.

11. Sila Gulbag, Alptug Karakucuk, Nevin Celebi, "Preparation and characterization of cyclosporine nanosuspension for oral administration I: Effects of formulation parameters", GPSS International Gazi Pharma Symposium Series 2, October 11-13, 2017, Ankara, Turkey.

12. Merve Celik Tekeli, Alptug Karakucuk, Yesim Aktas, Nevin Celebi, "Development of a self-emulsifying drug delivery system by design of experiment (DoE) approach", GPSS International Gazi Pharma Symposium Series 2, October 11-13, 2017, Ankara, Turkey.

13. Emine Tashan, Alptug Karakucuk, Nevin Celebi, "Preparation of orally dispersible tablets of ziprasidone hydrochloride monohydrate nanocrystals: The Quality by Design (QbD) approach", 7th BBBB International Conference on Pharmaceutical Sciences, October 5-7, 2017, Balatonfüred, Hungary.​

14. Alptug Karakucuk, Zeynep Safak Teksin, Nevin Celebi, "Evaluation of fasted and fed bioavailabilities of ritonavir nanosuspension in rats", Controlled Release Society Annual Meeting & Exposition, July 16-19, 2017, Boston, Massachusetts, USA.

15. Alptug Karakucuk, Naile Ozturk, Imran Vural, Zeynep Safak Teksin, Nevin Celebi, "In vitro CACO-2 cell permeability studies of ritonavir nanosuspension formulation", 6th FIP Pharmaceutical Sciences World Congress 2017, May 21-24, 2017, Stockholm, Sweden.

16. Serdar Tort, Alptug Karakucuk, Nevin Celebi, Fusun Acarturk, "Electrospun PCL Nanofiber composites of resveratrol nanocrystals: Production, Characterization and Antimicrobial Activity", 6th FIP Pharmaceutical Sciences World Congress 2017, May 21-24, 2017, Stockholm, Sweden.

17. Alptug Karakucuk, Hande Canpinar, Nevin Celebi, "Determination of lymphocyte sub-groups after administration of ritonavir nanosuspensions orally using flow cytometry", The 22nd Biomedical Science and Technology Symposium (BIOMED 2017), May 12-14, 2017, Ankara, Turkey.

18. Emine Taşhan, Alptuğ Karaküçük, Nevin Çelebi, "Evaluation of Solubility and Dissolution Profiles of Ziprasidone Hydrochloride Monohydrate Nanosuspensions", 18th International Pharmaceutical Technology Symposium (IPTS), September 18-21, 2016, Antalya, Turkey.

19. Alptug Karakucuk, Nevin Celebi, Zeynep Teksin, "Evaluation of solubility and dissolution of ritonavir nanosuspensions", 4th Congress on Innovation in Drug Delivery Site-Specific Drug Delivery, September 25-28, 2016, Antibes-Juan-les-Pins, France.

20. Alptuğ Karaküçük, Nevin Çelebi, "Characterization and optimization of ritonavir nanosuspension formulations using different stabilizers: III. Application of the factorial design", 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, April 4-7, 2016, Glasgow, United Kingdom.

21. Ayşe Nur Oktay, Sıla Gülbağ, Özden Demirtaş, Duygu Yılmaz Usta, Hazal Ezgi Gültekin, Alptuğ Eren Karaküçük, Nevin Çelebi "New Perspective For Memantine Orally Disintegrating Tablet: SeDeM Expert System", GPSS International Gazi Pharma Symposium Series, November 12-15, 2015, Antalya, Turkey.

22. Alptuğ Karaküçük, Nevin Çelebi, "Preparation and Characterization of HPMC Stabilized Nanosuspensions: II. Considering Interactions Between Formulation Parameters", 2015 AAPS Annual Meeting and Exposition, October 25-29, 2015, Orlando, USA.

23. Emine Taşhan, Alptuğ Karaküçük, Nevin Çelebi, "Preparation of Ziprasidone Hydrochloride Monohydrate Nanosuspensions Through Desing of Experiment (DoE)", 2015 AAPS Annual Meeting and Exposition, October 25-29, 2015, Orlando, USA.

24. Alptuğ Karaküçük, Nevin Çelebi, Zeynep Şafak Teksin, “Effect of stabilizers on the particle size reduction and physical stability of ritonavir nanosuspensions” 2014 AAPS Annual Meeting and Exposition, November 2-6, 2014, San Diego, USA.

25. Emine Taşhan, Alptuğ Karaküçük, Nevin Çelebi, “Preparation of ziprasidone nanosuspensions by microfluidization technique using different stabilizers”, 17th International Pharmaceutical Technology Symposium (IPTS), September 8-10, 2014, Antalya, Turkey.

26. Gülen Melike Demir, Alptuğ Karaküçük, Zelihagül Değim, Derya Bektaş, Özlem Çoban, Ezgi Gülpınar, Sema Tuna Torunoğlu, “Stirring Speed Effects On Physical Characteristics Of Theophylline Microsphere”, Proceedings of the 5th International Conference on Nanotechnology: Fundamentals and Applications August 11-13, 2014, Prague, Czech Republic.


Name SurnameAssist.Prof. Ece ÖZKAN
E-Mail[email protected]
Detail
Resume

Assist.Prof. Ece ÖZKAN

Gazi University 2009 Hacettepe University Hacettepe University

Previous Positions

Hacettepe University
Baskent University

Research Areas

Analytical Chemistry
Electrochemistry
Metabolomics
Gas Chromatography-Mass Spectrometry
Liquid Chromatography-Mass Spectrometry
Nanosensors
Metabolites
Molecular Imprinted Polymer
High Performance Liquid Chromatography
Drug Analysis
Biosensors

Selected Publications / All Publications

Name SurnameAssist.Prof. Erva ÖZKAN
E-Mail[email protected]
Detail
Resume

Assist.Prof. Erva ÖZKAN

Ankara University Ankara University Ankara University

Previous Positions

Research Areas

Cancer biochemistry, Cell death mechanisms, Cell signaling, Chemotherapeutics, Antioxidants

Selected Publications / All Publications

Publications:

 Gultekin I, Ozkan E, Bakar-Ates F, Bozdag-Dundar O. 2023. New Flavone Derivatives Targeting BET Proteins in Cancer: Synthesis, Structure Analysis and Investigation of Bromodomain Inhibitory Activities. ChemistrySelect. http://doi.org/10.1002/slct.202302492

 Bakar-Ates F, Ozkan E. 2023. Cucurbitacin B and erastin co-treatment synergistically induced ferroptosis in breast cancer cells via altered iron-regulating proteins and lipid peroxidation. Toxicol In Vitro. 2023;105732. http://doi:10.1016/j.tiv.2023.105732

 Ozkan E, Bakar-Ates, F. 2023. Cuproptosis as the new kryptonite of cancer: a copper‑dependent novel cell death mechanism with promising implications for the treatment of hepatocellular carcinoma. Journal of Cancer Research and Clinical Oncology, http://doi.org/10.1007/s00432-023-05456-w

 Topal, G.R., Kucukturkmen, B., Oz, U.C., Ozkan, E., Bakar-Ates, F., Bozkır, A. 2023. Investigation on formulation parameters of donepezil HCl loaded solid lipid nanoparticles. Braz. J. Pharm. Sci. 59:e22330 p1-11. http://dx.doi.org/10.1590/s2175-97902023e22330

 Ozkan E, Bakar-Ates F. 2023. Etoposide in combination with erastin synergistically altered iron homeostasis and induced ferroptotic cell death through regulating IREB2/FPN1 expression in estrogen receptor positive-breast cancer cells. Life Sciences, 312:121222. http://doi.org/10.1016/j.lfs.2022.121222

 Bakar-Ates F, Ozkan E. 2023. Atorvastatin induces downregulation of matrix metalloproteinase-2/9 in MDA-MB-231 triple negative breast cancer cells. Medical Oncology. 40:22. http://doi.org/10.1007/s12032-022-01880-z

 Sengel-Turk CT, Ozkan E, Bakar-Ates F. 2022. Box-Behnken Design Optimization and In Vitro Cell Based Evaluation of Piroxicam Loaded Core-Shell Type Hybrid Nanocarriers for Prostate Cancer. J. Pharm. Biomed. 216:114799. http://doi.org/10.1016/j.jpba.2022.114799

 Gozelle M, Kaya SG, Aksel AB, Ozkan E, Bakar-Ates F, Ozkan Y, Eren G. 2022. Hit evaluation results in 5-benzyl-1,3,4-thiadiazole-2-carboxamide based SIRT2-selective inhibitor with improved affinity and selectivity. Bioorg. Chem. 123:105746.
http://doi.org/10.1016/j.bioorg.2022.105746

 Ozkan E, Bakar-Ates, F. 2022. Ferroptosis: A Trusted Ally in Combating Drug Resistance in Cancer. Curr Med Chem. 29(1):41-55.
http://doi.org/10.2174/0929867328666210810115812

 Ozkan E & Bakar-Ates F. 2020. Potentiation of the Effect of Lonidamine by Quercetin in MCF-7 human breast cancer cells through downregulation of MMP-2/9 mRNA Expression. An Acad Bras Cienc 92:e20200548. https://doi.org/10.1590/0001-3765202020200548

 Bakar-Ates F, Ozkan E, Sengel Turk CT. 2020. Encapsulation of cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage. Int J Pharm. 586:119565. https://doi.org/10.1016/j.ijpharm.2020.119565

 Ozkan E, Bakar-Ates, F. 2020. The Trinity of Matrix Metalloproteinases, Inflammation, and Cancer: A Literature Review of Recent Updates. Antiinflamm Antiallergy Agents Med Chem. 19(3):206-221. https://doi.org/10.2174/1871523018666191023141807

 Bakar Ates, F.; Ozkan, E. 2019. The Combined Treatment of Brassinin and Imatinib Synergistically Downregulated the Expression of MMP-9 in SW480 Colon Cancer Cells. Phytother Res. 33(2):397-402. https://doi.org/10.1002/ptr.6233

Book Chapters:
 Ozkan E & Bakar-Ates F. 2022. Resistin: An Irresistible Therapeutic Target for Inflammatory Diseases, Allergy-Related Disorders, and Cancer. In A.-U. Rahman (Ed.), Frontiers in Clinical Drug Research – Anti Allergy Agents (5th vol., pp. 1-40). Bentham Science. http://doi.org/10.2174/9789815040616122050003

Oral Presentations:
 3rd International Multidisciplinary Cancer Research Congress, Istanbul, Turkiye. 07-10 September 2023.
Presentation Title: Ozkan, E., Bakar-Ates, F. The Anticancer Potential of Brassinin In Estrogen Receptor-Positive Breast Cancer Cells Through The Activation Of Apoptosis And Downregulation Of Matrix Metalloproteinase-2

 Congress of the Croatian Society of Biochemistry and Molecular Biology (HDBMB 2019)- Croatia
Presentation Title: Bakar-Ates, F.; Ozkan, E. The Apoptotic Effect of Atorvastatin in MDAMB231 cells is related with down-regulation of MMP-2/9 mRNA Expression.

 The 7th Drug Chemistry Conference (2019)-Turkey
Presentation Title: Bakar-Ates, F.; Ozkan, E.; Sengel-Turk, C.T. Effects of Cucurbitacin B Hybrid Nanocarriers on Apoptosis of MDAMB231 Cells Through PARP Cleavage.

 The 12nd International Symposium on Pharmaceutical Sciences (ISOPS 2018) –Turkey
Presentation Title: Ozkan, E.; Bakar Ates, F. Brassinin Synergistically Induced Anticancer Effects of Imatinib in SW480 Colon Cancer Cells.

 TBS International Biochemistry Congress (2018) – Turkey
Presentation Title: Bakar Ates, F.; Ozkan, E.; Sengel Turk, C.T. Anticancer effect of cucurbitacin b loaded hybrid nanocarriers on human breast cancer cells.

 HDIR-5, “Translating Science to Medicine:Targets and Therapeutics (2018)- Zagreb, Croatia
Presentation Title: Bakar Ates, F.; Ozkan, E.; Sengel Turk, C.T. Cucurbitacin B Loaded Lipid Polymer Hybrid Nanocarriers Induced a Significant Decrease in Mitochondrial Membrane Potential in Breast Cancer Cells.

 10th International Symposium on Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI)-Ioannina, Greece, 23-27 June, 2019.
Presentation Title: Bozdag-Dundar O., Yüceilyas I., Ozkan E., Bakar-Ates F. Synthesis of some novel flavonyl sulfamoyl quinozalinone compounds as anticancer agents.

Poster Presentations:
 The 43rd FEBS Congress (2018) – Prague / Czech Republic
Poster Title: Ozkan, E.; Bakar-Ates, F. The Dose-Dependent Effects Of Brassinin On Apoptosis In SW480 Colorectal Cancer Cells Through MMP-9 Related Pathway.

 The 2nd International Gazi Pharma Symposium Series (GPSS 2017) -Turkey
Poster Title: Ozkan, E.; Ozmen, N.; Bakar, F. The effects of Lonidamine and Quercetin combination on cell growth and apoptosis of MCF-7 breast cancer cells.

Name SurnameAssist.Prof. Fatma TAEB DİŞLİ
E-Mail[email protected]
Detail
Resume

Assist.Prof. Fatma TAEB DİŞLİ

Gazi University 2002 Gazi University Gazi University

Previous Positions

Research Areas

Selected Publications / All Publications

Uluslararası hakemli dergilerde yayımlanan makaleler:
Zarre, S., Podlech, D., Taeb, F. (2005). New species of genus Astragalus L. (Fabaceae), mainly from the Flora Iranica area. Feddes Repertorium 116(1-2): 54-79.Özüdoğru, B.,
Taeb, F., Zarre, S., Podlech, P., Tillich, H.J., Kazempour Osaloo S., Maassoumi, A.A. (2007). A contribution to the phylogeny of annual species of Astragalus (Fabaceae) in the Old World using hair micromorphology and other morphological characters. Feddes Repertorium 118(5-6): 206-227.
Özüdoğru, B., Erik, S., Taeb, F. (2011). Astragalus pseudopinetorum (Fabaceae) a new species from Turkey. Ann. Bot. Fennici 48: 84-86.
Taeb, F., Uzunhisarcıklı, M.E. (2012). Astragalus argentophyllus (Fabaceae), a new species from south Anatolia, Turkey. Ann. Bot. Fennici 49: 259-262.
Taeb, F., Ekici, M., Podlech, D. (2012). Taxonomic revision of annual species of Astragalus L. (Fabaceae) in Turkey. Feddes Repertorium 123(1): 1-26.

Bilimsel toplantılarda sunulan ve bildiri kitaplarında (proceedings) basılan bildiriler:
Taeb, F., Zarre, S, Maassoumi, A.A., Ghahreman. A. (2004). A Contribution to Systematics of Annual Species of Astragalus (Fabaceae) in the Old World. 12th Congress of Biology, 20-22 Agust, Hamedan University, Iran.
Taeb, F., Zarre, S., Podlech, D., Tillich, H.J., Kazempour Osaloo, S., Maassoumi, A.A. (2005). A contribution to the systemarics of annual species of Astragalus (Fabaceae) in the Old World. XVII International Botanical Congress, 17-23 July 2005, Vienna.
Taeb, F., Maassoumi, A.A., Podlech, D., Ghahreman, A. (2005). A Contribution to Phylogeny of Annual Species of Astragalus (Fabaceae) in the Old World. 14th and first International Congress of Biology, 23-25 Agus. Guilan University, Iran.
Taeb, F., Zarre, S., Maassoumi, A.A., Kazempour Osaloo, S. (2006). Heterogeneity and polyphyly of Astragalus sect. Sesamei (Fabaceae) based on morphological and biogeographical evidences. First National Congress of Biotechnology and Biocatalists, 20-21 November, Azad University, Iran.
Taeb, F., Zarre, S., Maassoumi, A.A., Kazempour Osaloo, S. (2007). Evidences on polyphyly of Astragalus sect. Annulres (Fabaceae). 1th National Congress of Plant Taxonomy, 6 September, Research Institute of Forests and Rangelands, Tehran, Iran.
Taeb, F. Dönmez, A.A., Zarre. S. (2009). Notes on Annual species of Astragalus (Fabaceae) in Turkey. The 80th anniversary of Turrill’s “PLANT LIFE OF THE BALKAN PENINSULA” (5th Balkan Botanical Congress). 7-11th September, Belgrad, Serbia.
Taeb, F., Ekici, M., Podlech, D. (2011). Notes on Astragalus suberosus species complex in Turkey.7 th International Congress of Systematic and Evolutionary. Biology (ICSEB VII)“BIOSYSTEMATICS BERLIN”. 21-27th February, Berlin, Germany
Taeb, F., Zarre, S., Maassoumi, A.A., Kazempour Osaloo, S. (2007). Heterogeneity and polyphyly of Astragalus sect. Sesamei (Fabaceae) based on morphological and biogeographical evidences. International Congress Symposium 7th Plant Life of South West Asia (7thPLoSWA), 25-29 June, Eskişehir, Turkey.
Taeb, F., Uzunhisarcıklı, M.E., Ekici, M. (2012). Threat categories of some endemic species of Astragalus sect. Malacothrix (Fabaceae). 2 th Biorare Endemik Plants Congre, Fethiye, Muğla, Turkey.

Name SurnameAssist.Prof. Gizem ARIK
E-Mail[email protected]
Detail
Resume

Assist.Prof. Gizem ARIK

Anadolu University 2009 Eskisehir Technical University Eskisehir Technical University

Previous Positions

Research Areas

Microbiology

Selected Publications / All Publications

1. Uluslararası hakemli dergilerde yayınlanan makaleler (SCI & SSCI & Arts and Humanities)
- Yılmaz Cankılıç, M., Arık, G. (2016), Analysıs of cyanobacterial diversity of some hot springs in Afyonkarahisar, Turkey. Applied Ecology and Environmental Research, 14(2): 463-484.
- Kıvanç, S. A., Arık, G., Akova Budak, B., Kıvanç, M. (2018), Biofilm forming capacity and antibiotic susceptibility of Staphylococcus spp. with the icaA/icaD/bap genotype isolated from ocular surface of patients with diabetes, Malawi Medical Journal, 30(4): 243-249.
- Er, S., İstanbullu Tosun, A., Arık, G., Kıvanç, M. (2018). Anticandidal activities of lactic acid bacteria isolated from the vagina. Turkish Journal of Medical Science, doi:10.3906/sag-1709-143.
- Kalyoncu, S., Yilmaz, S., Kuyucu, A.Z. et al. Process development for an effective COVID-19 vaccine candidate harboring recombinant SARS-CoV-2 delta plus receptor binding domain produced by Pichia pastoris. Sci Rep 13, 5224 (2023). https://doi.org/10.1038/s41598-023-32021-9
-Oyku Simsekli, Irfan Bilinmis, Sumeyye Celik, Gizem Arık, Abdullah Yucel Baba & Alptug Karakucuk (2023) Advancing biofilm management through nanoformulation strategies: a review of dosage forms and administration routes, Journal of Drug Targeting, DOI: 10.1080/1061186X.2023.2270619

2. Uluslararası diğer hakemli dergilerde yayınlanan makaleler
- Köseoğlu-Tetik, Z., Şanal-Demirci, S., Arık G. (2019). Isolated and identified bacteria from digestive systems of blood- sucking tabanidae (Insecta: Diptera). International Journal of Entomology Research, 4(6):68-73.
-Arık, G., Yılmaz Sarıözlü, N. (2021). Determination of lipase activities of actinomycetes isolates from soil. Biological Diversity and Conservation, 14/3 (2021) 487-492.
-Arik, G., Kivanc, M., & KIRZIOĞLU, Z., (2022). Diversity of aerobic and facultative anaerobic bacteria forming the supragingival biofilm in healthy children. MALAYSIAN JOURNAL OF MICROBIOLOGY , vol.18, no.5, 555-561.

3. Uluslararası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceedings) basılan bildiriler
- Arık, G., Yılmaz Sarıözlü, N. (2011), Determining of Antimicrobial Activity of Actinomycetes Isolated from Different Soil Samples The 4th Congress of European Microbiologists (FEMS), Geneva, İsviçre, 26-30 Haziran.
- Arık, G., Yılmaz, M. (2011), Identification of Thermophilic Cyanobacteria Isolates Obtained from AfyonkarahisarCity-TURKEY IV International Conference on Environmental, Industrial and Applied Microbiology BioMicroWorld , Malaga-İspanya, 14-16 Eylül.
- Berikten, D., Hosgün, E. Z., Arik, G., Yilmaz, Y., Bozan, B., Kivanc, M. (2013), Screening of White Rot Fungal Species for Their Capacity to Increase Enzymatic Hydrolysis of Hazelnut Shell, V. International Conference Environmental, Industrial and Applied Microbiology, Madrid, İspanya 2-4 Ekim.
- Arık, G., Kıvanç, M. (2015), In vitro investigation of biofilm formation capacity of oral lactic acid bacteria isolates on different carbonhydrates, World Congress on Beneficial Microbes: Food, Pharma, Aqua & Beverages Industry Valensiya, İspanya.
- Arık, G., Kıvanç, M. (2019), Oral laktik asit bakterilerinin antioksidan aktivitelerinin belirlenmesi, 2. Uluslararası Sağlık Bilimleri ve Yaşam Kongresi, Burdur, Türkiye 24-27 Nisan.

4. Yazılan uluslararası kitaplar veya kitaplarda bölümler
- Berikten, D., Hoşgün E. Z., Arık, G., Yılmaz, Y., Bozan B., Kıvanç, M. (2014). Screening of White Rot Fungal Species for Their Capacity to Increase Enzymatic Hydrolysis of Hazelnut Shell. Industrial, Medical and Environmental Applications of Microorganisms. Current Status and Trends, A. Mendez-Vilas, Editör, Wageningen Academis Publishers, ss.630-634.

5. Ulusal bilimsel toplantılarda sunulan ve bildiri kitabında basılan bildiriler
Berikten, D., Hoşgün, E. Z., Arık, G., Bozan, B., Kivanç, M. (2014). Bazı Mikrofungus Türlerinin Selülaz ve Ksilanaz Aktivitelerinin Araştırılması, 22. Ulusal Biyoloji Kongresi, Eskişehir, 23-27 Haziran (poster sunumu).

6. Diğer yayınlar
- Arık, G. Bakteri Destekli Biyomürekkep Üretimi. (2020). Medikal İnovatif Teknolojiler, Arslantaş, A., Aydın H. E., Editör. Eskişehir Osmangazi Üniversitesi Yayınları, ss. 33-42

7. Ulusal & Uluslararası Projeler
Afyon ve Kütahya bölgesindeki bazı termal kaynakların sianobakteri biyoçeşitliliğinin belirlenmesi. BAP-Genel Amaçlı Projeler-Proje Numarası: 1002F85- Araştırmacı (Tamamlandı)
Aktinomiset Kaynaklı Lipaz Geninin Klonlanması, Dizilenmesi ve Ekspresyonu. BAP-Yüksek Lisans Tez Projesi-1005F114-Araştırmacı (Tamamlandı)
Oral Laktik Asit Bakterilerinin Biyofilm ve Halitosis Üzerine Etkilerinin İn Vitro Araştırılması. BAP-Doktora Tez Projesi-Proje Numarası: 1408F371- Araştırmacı (Tamamlandı)
Üst çene bölgesinde mini vida destekli ortodontik apareyler ile yapılan tedaviler sonrasında çıkarılan mini vidaların mikrobiyolojik olarak değerlendirilmesi. BAP-Genel Amaçlı Projeler-Proje Numarası: 1710F535-Araştırmacı (Tamamlandı)
SARS-CoV-2’ye Karşı Rekombinant Protein Temelli Aşı Geliştirilmesi-TÜBİTAK-2247-C STAR Stajyer Araştırmacı Burs Programı-Doktora Sonrası Araştırmacı